Activities undertaken over the past ten years have included Drug and Alcohol Service, Asthma Education, Suicide Prevention, Aboriginal Otitis Media and Aboriginal Diabetes Awareness and Prevention Programs, Men's Health, Chronic Pain Management, Diabetes Educator Program, Cardiac Rehabilitation, Integration of Diabetes Program and Consumer Liaison. In more recent years the Division has focused on a whole of practice approach and developed comprehensive workforce support strategies, practice management support, IM/IT support, quality education & training, chronic diseases support, population health strategies, general practice integration strategies and general practice advocacy.

The Division covers an area of 52,214 square kilometres of South East New South Wales. It surrounds the ACT and is 350 kilometres long and 259 kilometres wide. The Division extends from Batemans Bay on the south coast to the Victorian border; it then runs inland thru the Snowy Mountains taking in Cooma and Jindabyne, out west to Yass and north to Young and includes the towns of Goulburn and Queanbeyan. It is a minimum of a three hour drive to the furthermost points in the region. The South East NSW Division of General Practice is bordered by the Divisions of Shoalhaven and Southern Highlands to the north, East Gippsland to the south, Riverina to the west and the ACT Division in the centre.

The region is wholly rural with some remote areas and includes the two regional centres of Goulburn and Queanbeyan. There are 16 local government areas which the Division has divided into seven networks:

• Eurobodalla
• The Far South Coast
• Cooma / Snowy Mountains
• Yass
• Young and District
• Queanbeyan and District
• Goulburn and District